Zapomeran

mRNA-2105 RNA (recombinant 5′-(m7G-(5′→5′)-ppp-Am)-capped Venezuelan equine encephalitis virus RNA-dependent RNA polymerase codon-optimized transgene plus severe acute respiratory syndrome coronavirus 2 spike pre-fusion glycoprotein [614-glycine,682-glycine,683-serine,685-serine,986-proline,987-proline] precursor-specifying plus 5′- and 3′-untranslated flanking region-containing poly(A)-tailed messenger mRNA-2105), inner salt self-replicating messenger RNA (mRNA), 5'-capped, encoding codon-optimised Venezuelan equine encephalitis virus (VEEV) RNA-dependent RNA polymerase (VEEV proteins nsP1, nsP2, nsP3 and nsP4) and a full-length codon-optimised pre-fusion stabilised conformation variant (K986P and V987P) of the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) spike (S) glycoprotein (derived from GenBank ID YP_009724390) containing furin cleavage-inactivating mutations (R682G, R683S,R685S) plus an additional mutation (D614G), flanked by 5' and 3' untranslated regions and a 3' polyadenylation (polyA) tail and generation of the capped S mRNA is under control of a VEEV subgenomic promoter. zapomeran [INN]