ZEVORCABTAGENE AUTOLEUCEL

AUTOLOGOUS ANTI-BCMA-CAR-4-1BB-CD3ZETA-EXPRESSING T-CELLS CT053 CT-053 CT053 PREPARATION OF AUTOLOGOUS T-LYMPHOCYTES THAT HAVE BEEN TRANSDUCED WITH A VECTOR EXPRESSING A CHIMERIC ANTIGEN RECEPTOR (CAR) CONTAINING A HUMANIZED SINGLE CHAIN VARIABLE FRAGMENT (SCFV) SPECIFIC FOR THE TUMOR-ASSOCIATED ANTIGEN (TAA) B-CELL MATURATION ANTIGEN (BCMA; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 17; TNFRSF17) THAT IS FUSED TO THE CO-STIMULATORY DOMAIN OF 4-1BB (CD137) AND THE T-CELL RECEPTOR SIGNALING DOMAIN OF CD3ZETA (CD3Z), WITH POTENTIAL IMMUNOSTIMULATING AND ANTINEOPLASTIC ACTIVITIES. UPON ADMINISTRATION, THE AUTOLOGOUS ANTI-BCMA-CAR-4-1BB-CD3ZETA-EXPRESSING T-CELLS CT053 SPECIFICALLY RECOGNIZE AND INDUCE SELECTIVE TOXICITY AGAINST BCMA-EXPRESSING TUMOR CELLS. zevorcabtagene autoleucel [INN] ZEVORCABTAGENE AUTOLEUCEL [USAN] Zevorcabtagene autoleucel [WHO-DD]