Zadoprubart

H-gamma4 heavy chain humanized (1-451) [VH (Homo sapiens IGHV1-69*08 (80.6%) -(IGHD) -IGHJ6*05 (92.3%) A127>S (123), CDR-IMGT [8.8.17] (26-33.51-58.97-113)) (1-124) -Homo sapiens IGHG4*01, nG4m(a) CH2 L92, G4v5 h P10(CH1 (125-222), hinge 1-12 S10>P (232) (223-234), CH2 L92 (313) (235-344), CH3 (345-449), CHS (450-451)) (125-451)], (138-214')-disulfide with L-kappa light chain humanized (1'-214') [V-KAPPA (Homo sapiens IGKV1-12*01 (86.4%) -IGKJ4*01 (100%), CDR-IMGT [6.3.9] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (153'), V101 (191')) (108'-214')]; dimer (230-230'':233-233'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa Immunoglobulin G4, anti-(human/Macaca fascicularis protein BTLA (B-and T-lymphocyte attenuator)) (human-Mus musculus monoclonal ANB032 γ4-chain), disulfide with human-Mus musculus monoclonal ANB032 κ-chain, dimer immunoglobulin G4-kappa, anti-[Homo sapiens BTLA (B and T lymphocyte attenuator, BTLA1, CD272)], humanized monoclonal antibody zadoprubart [INN]